MOLECULAR EPIDEMIOLOGY OF PLASMODIUM FALCIPARUM RESISTANCE TO ANTIMALARIAL DRUGS IN INDONESIA
نویسندگان
چکیده
منابع مشابه
Molecular epidemiology of Plasmodium falciparum resistance to antimalarial drugs in Indonesia.
The extent of gene polymorphisms associated with resistance to chloroquine and sulfadoxine-pyrimethamine was examined in field isolates of Plasmodium falciparum from Indonesia. Eight malaria-endemic areas, representing a broad region of the western and eastern Indonesian Archipelago were surveyed. Blood from 20-50 patients was collected at each site, DNA was isolated, and the sequences of four ...
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In vivo and in vitro assessments of the response of P. falciparum to chloroquine using WHO standard kits and techniques were carried out in I ran Shahr, Sistan and Baluchestan province of Iran in 1985. In the in vivo assessment, 24 malaria patients treated with chloroquine (25mg/kg over three days) were followed up for one to four weeks. The mean parasite clearance time was 4.3 days and in...
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The Plasmodium parasite is a eukaryotic unicellular pathogen and the causative agent of the tropical disease malaria. Malaria is caused by five species of the genus Plasmodium that affect humans: P. falciparum, P. vivax, P. ovale, P. malariae and P. knowlesi. Parasites are transmitted to humans by the bite of infected female mosquitoes of more than 30 anopheline species. Up to date, malaria con...
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Malaria control is compromised by the development and spread of Plasmodium falciparum resistance to antimalarial drugs, which has caused an increase in malaria related morbidity and mortality. Artemisinin based combination therapy (ACT) has been implemented in almost all malaria endemic areas in an attempt to suppress drug resistance. The ACT artemether-lumefantrine (Coartem®; Novartis) is one ...
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ژورنال
عنوان ژورنال: The American Journal of Tropical Medicine and Hygiene
سال: 2005
ISSN: 0002-9637,1476-1645
DOI: 10.4269/ajtmh.2005.72.174